Research

   Prominent researchers in finding a cure for A-T

Richard Gatti, MD 
UCLA School of Medicine

Yosef Shiloh,  PhD
Sackler School of Medicine,
Tel Aviv University

Research Grants Currently Supported by A-T Ease Foundation

2015-2016

In search of the molecular basis of the cerebellar degeneration in ataxia-telangiectasia (A-T)
Yosef Shiloh, Ph.D.
Department of Human Molecular Genetics and Biochemistry
Sackler School of Medicine
Tel Aviv University

2014

Diagnostic Testing and Tissue Culture of Cells Necessary for SMRT Drug Testing
Richard A. Gatti, MD
Rebecca Smith Distinguished Professor
David Geffen School of Medicine at UCLA

In search of the molecular basis of the cerebellar degeneration in ataxia-telangiectasia (A-T)
Yosef Shiloh, Ph.D.
The David and Inez Myers Chair in Cancer Research
Sackler School of Medicine, Tel Aviv Universit
y

2013

Establish a Breeding Colony to be used to Test the Effectiveness of Promising Read-through Drugs
Richard Gatti, MD 
UCLA School of Medicin
e  

In search of the molecular basis of the cerebellar degeneration in Ataxia-Telangiectasia
Yosef Shiloh,  PhD
Sackler School of Medicine, Tel Aviv University

The Ataxia-Telangiectasia Clinical Center
Principal Investigator – Howard Lederman, MD  PhD
Johns Hopkins Children’s Center

2012
Development of Small Molecule Read-through (SMRT) Compounds
Richard Gatti, MD 
UCLA School of Medicine 

 
In search of the molecular basis of the cerebellar degeneration in ataxia-Telangiectasia (A-T)
Yosef Shiloh, PhD
Sackler School of Medicine, Tel Aviv University

Investigating Connectivity and Neuroinflammation within Corticomotor Networks in Ataxia-Telangiectasia: Improving our Understanding of the Clinical Phenotype
Principal Investigator – Stephen Rose, Kate Sinclair MD, Martin Lavin PhD
 University of Queensland, Australia

Addressing Neurological Dysfunction in Ataxia Telangiectasia:  Investigation into Novel, Physiologic ATM Activation in Neurons and ATM-PP1 Signaling in Reorganization and Refinement of Post Synaptic Architecture
Principal Investigator – Benjamin Siddoway, B.Sc.
 Louisiana State University Health Science Center

Research Grants Supported in the Past by A-T Ease Foundation

ATM in Immune Responses
Principal Investigator – Jessamyn Bagley, PhD
Case Western Reserve University

Direct Research on Ataxia-Telangiectasia
Principal Investigator – Richard Gatti, MD
UCLA School of Medicine

ATM’s Function in Neuronal Cells
Principal Investigator – Yosef Shiloh, PhD
Sackler School of Medicine, Tel Aviv University

Direct Research on Ataxia-Telangiectasia
Principal Investigator – Yosef Shiloh, PhD
Sackler School of Medicine, Tel Aviv University

The Role of Pro-Apoptotic BID as an ATM Effector in the DNA-Damage Response
Principal Investigator – Atan Gross, PhD
Weizmann Institute of Science

Cell Cycle Events in Ataxia Telangiectasia: Human and Mouse
Co-Principal Investigators –Yan Yang, PhD and Karl Herrup, PhD
Case Western Reserve University

The Function of ATM in Neuronal Differentiation: Identification of Targets for High Throughput Screening
Principal Investigator- Brendan Price, PhD
Dana-Farber Cancer Institute

Direct Research on Ataxia-Telangiectasia
Principal Investigator Yosef Shiloh, PhD
Sackler School of Medicine, Tel Aviv University

Iron Chelation and Aspirin as a Pharmacological Treatment to Increase the Life-Span of Ataxia- Telangiectasia Mice.
Principal Investigator Suming Wang, MD, PhD
Co-Principal Investigator Rodney Shackelford, DO, PhD
Stoddard Cancer Research Institute

Mechanisms of Neurodegeneration in Ataxia-Telangiectasia
Principal Investigator Allen Mandir, MD, PhD
Johns Hopkins Hospital/Georgetown University School of Medicine

Direct Research on Ataxia-Telangiectasia
Principal Investigator Richard Gatti, MD
UCLA School of Medicine

Experimental Gene Therapy for Ataxia-Telangiectasia
Principal Investigator Xandra Breakefield, PhD and Marisa Cortes, PhD
Massachusetts General Hospital

A-T Clinical Trial Oxidative Stress in Patients with Ataxia-Telangiectasia
Principal Investigator - Howard Lederman, MD, PhD
A-T Clinical Center at Johns Hopkins Hospital
(A-T Ease will be sponsoring participants in this clinical trial.)

Introduction of Hematopoietic Chimerism for Treatment of Immune System Defects in Ataxia- Telangiectasia.
Principal Investigator John Iacomini, PhD
Massachusetts General Hospital